General Clinical Chemistry Analyzers and Accessories
Rarecyte RareCyte RarePlex BT-474 spike-in CTC Control Slide, 10-Pack
A pack of ten, batch control slides to be stained, scanned, and reviewed with experimental slides. Control slides contain a monolayer of buffy coat and spiked-in BT-474 cells (epithelial cells from human breast carcinoma). This control slide is used to assess the performance of the immunofluorescent staining process for the detection of CTCs. Cells may be identified by biomarkers: Nuclear DNA, CK/EpCAM, CD45, HER2 and ER. Compatible kits: RareCyte RarePlex HER2/ER CTC Panel Kit, Ventana (SYTOX) (24-1257-002); CTC Panel Kit, Ventana (SYTOX) (24-1245-002); CTC Panel Kit, Leica (SYTOX) (24-1245-001); CTC Panel Kit, Ventana (Hoechst) (24-1277-002); CTC Panel Kit, Leica (Hoechst) (24-1277-001); CTC Panel Kit, Manual Staining (Hoechst) (24-1277-004); PD-L1 CTC Panel Kit, Ventana (24-1280-002); Developer Kit: 488 nm, Leica (28-1001-481); 405 nm, Leica (28-1001-401); 405 nm, Ventana (28-1001-402); 488 nm, Ventana(28-1001-482) and Cell Discovery Kit, Leica (24-1294-001).
Abcam INDY, DYRK1A/B inhibitor, 5MG
MW 235.3 Da, Purity >98%. Potent DYRK1A/B inhibitor (IC₅₀ values are 0.23 and 0.24 μM for DYRK1B and DYRK1A respectively). Also inhibits DYRK2, DTRK4, CLK1, CLK4, casein kinase 1 and PIM1 (> 90% inhibition at 10 μM). Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of neural stem cells and glioblastoma tumor-initiating cells.
The product is subject to the following: Abcam Restricted Use Statement
Abcam LY2886721, BACE-1 inhibitor, 25MG
MW 390.4 Da, Purity >98%. Potent and selective BACE-1 inhibitor (IC₅₀ = 20.3 nM for recombinant hBACE-1). Human BACE2 is inhibited with an IC₅₀ of 10.2 nM. Does not inhibit other aspartyl proteases such as cathepsin D, pepsin, and renin. A potential agent to treat Alzheimer's Disease. Inhibits production of Aβ in HEK-293 Swe cells (IC₅₀ values are 18.5 nM and 19.7 nM for Aβ1-40 and Aβ1-42 respectively) and in PDAPP neuronal cells (IC₅₀ ~10 nM). Reduces dose-dependently brain levels of Aβ, C99 and sAPPβ in orally administered mouse model and plasma Aβ in dog model. Ppenetrates the blood-brain barrier.
The product is subject to the following: Abcam Restricted Use Statement
Abcam ABT-199 (Venetocla x ), Bcl-2 inhibitor., 5MG
MW 868.4 Da, Purity >98%. Potent, selective Bcl-2 inhibitor (Ki <0.01 nM) that inhibits the growth of Bcl-2–dependent tumors while sparing platelets. Bcl-2–specific BH3 mimetic. Promising agent in the treatment of chronic lymphocytic leukaemic and estrogen receptor-positive breast cancer.
The product is subject to the following: Abcam Restricted Use Statement
GENERAL BIOPHYSICS LLC Argon Gas Analyzer Model A
Thermoconductivity Gas Analyzer for Argon with Onboard PumpApplication: Calibrated for argon gas with onboard pump to take gas samples.Features: Includes data display screen.Accuracy: ±0.9%.
Perkin Elmer US LLC Sipper Cell and Pump Accessory
The Sipper Cell and Pump Accessory measures large numbers of liquid samples quickly and accurately. Samples can be transferred from a wide variety of containers to the flow cell. Includes: Synthetic Fused Silica flow cell, pathlength: 1.3 mm, cell volume: 16 mL (L2151247) Peristaltic pump controlled by computer Standard fitting 0.4 mm FEP Inlet Tube (L2151202) 0.7 mm FEP Outlet Tube (L2151203) Please note: This accessory requires installation by a PerkinElmer service engineer, not included.